Debre Berhan University Asrat Woldeyes Health Science Campus is located in the historic city of Debre Berhan, in the North Shewa Zone of the Amhara National Regional State. The campus features modern administrative buildings, libraries, laboratories, classrooms, and workshops, all supported by advanced and future-oriented digital technologies. It was established to provide high-quality education, research, and community services in the health sciences.

The naming of the campus recognizes Professor Asrat Woldeyes’ outstanding contributions to Ethiopia’s healthcare system. He was the country's pioneering surgeon, educator, and researcher. As a professor of surgery at Addis Ababa University College of Health Sciences, he played a significant role in the development and strengthening of medical education in Ethiopia. His dedication to patient care, teaching, and research left a lasting legacy in the nation's health sector.

When the campus began its teaching and learning activities, it had seven health science departments, 713 students, 199 academic staff members, and 134 administrative and technical staff members.

Over time, the campus has significantly expanded its capacity and academic programs. Currently, it offers 10 undergraduate programs, 17 master's programs, and 6 PhD program organized under five schools.